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Mitochondrial fission promotes cell migration by Ca2+ /CaMKII/ERK/FAK pathway in hepatocellular carcinoma.

Xiacheng SunHaiyan CaoLei ZhanChun YinGang WangPing LiangJibin LiZhe WangBingrong LiuQichao HuangJinliang Xing
Published in: Liver international : official journal of the International Association for the Study of the Liver (2018)
Taken together, our findings demonstrate that mitochondrial fission plays a critical role in the regulation of hepatocellular carcinoma cell migration, which provides strong evidence for this process as a drug target in hepatocellular carcinoma metastasis treatment.
Keyphrases
  • cell migration
  • oxidative stress
  • signaling pathway
  • cell proliferation
  • combination therapy