Peripheral helper T cells in the pathogenesis of multiple sclerosis.

Rikke Holm Holm HansenHelene Højsgaard ChowJacob TalbotSophie BuheltMarie Nathalie Nickelsen HellemJørgen Erik NielsenFinn Thorup SellebjergMarina Rode von Essen

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2022)

Altogether, we did not find an increased frequency of CSF Tph cells in patients with RRMS or PPMS. Our findings indicate that rather than being involved in MS pathogenesis, Tph cells may be implicated in normal CNS immunosurveillance.

Keyphrases

multiple sclerosis
induced apoptosis
cell cycle arrest
mass spectrometry
endoplasmic reticulum stress
cell death
signaling pathway
ms ms
dendritic cells
cell proliferation
chemotherapy induced