Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosis.

Weiping JiLu ChenWei YangKe LiJingting ZhaoCongcong YanCancan YouMinghua JiangMeng ZhouXian Shen

Published in: Cell & bioscience (2022)

The transcriptional landscape and the identification of critical subnetworks and risk genes of platelets provided novel insights into the molecular mechanisms of immunothrombosis in COVID-19 progression, which may pave the way for the development of novel therapeutic strategies for preventing COVID-19-associated thrombosis and improving the clinical outcome of COVID-19 patients.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
transcription factor
gene expression
bioinformatics analysis
single cell
pulmonary embolism
genome wide
heat shock protein