Blockage of autophagic flux is associated with lymphocytosis and higher percentage of tumoral cells in chronic lymphocytic leukemia of B cells.

J-R Romero-MacíasR Pascual-SerraO RocheF Ruiz-MarcosA Serrano-MartínezP González-AguadoB BelandiaM-J Ruiz-HidalgoRicardo Sanchez-Prieto

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)

Alterations in autophagic flux could play an important role in the physiopathology of chronic lymphocytic leukemia.

Keyphrases

chronic lymphocytic leukemia
cell death
cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
pi k akt