CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma.
Deepak RajMaria NikolaidiIrene GarcesDaniela LorizioNatalia M CastroSabrina G CaiafaKate MooreNicholas F BrownHemant Mahendrakumar KocherXiaobo DuanBrad H NelsonNicholas R LemoineJohn F MarshallPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
We identify CEACAM7 as a potential therapeutic target in PDAC and describe the development of CEACAM7-targeted CAR T cells with efficacy against PDAC.