CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway.
Nunzio Del GaudioAntonella Di CostanzoNing Qing LiuLidio ConteCarmela Dell'AversanaGuglielmo BoveRosaria BenedettiLiliana MontellaFortunato CiardielloVincenzo CarafaConcetta AmbrosinoValeria TucciMariarosaria ConteJoost H A MartensHendrik G StunnenbergAngela NebbiosoLucia AltucciPublished in: Molecular cancer (2022)
Our results identify CBX2 as a crucial player in leukemia progression and highlight a potential druggable CBX2-p38 MAPK network in AML.
Keyphrases
- acute myeloid leukemia
- signaling pathway
- allogeneic hematopoietic stem cell transplantation
- gene expression
- pi k akt
- dna damage
- transcription factor
- bone marrow
- genome wide
- epithelial mesenchymal transition
- induced apoptosis
- acute lymphoblastic leukemia
- risk assessment
- cell proliferation
- endoplasmic reticulum stress