Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation.

Jan SpaasWouter M A FranssenCharly KeytsmanLaura BlancquaertTim VanmierloJeroen BogieBieke BrouxNiels HellingsJack van HorssenDheeraj Kumar PosaDavid HoetkerShahid P BabaWim DeraveBert O Eijnde

Published in: Journal of neuroinflammation (2021)

Our results identify carbonyl (particularly acrolein) quenching by carnosine as a therapeutic strategy to counter inflammation and macromolecular damage in MS.

Keyphrases

oxidative stress
multiple sclerosis
mass spectrometry
ms ms
traumatic brain injury
lipopolysaccharide induced
cerebrospinal fluid
lps induced
cognitive impairment
cerebral ischemia
drug induced
blood brain barrier
brain injury