AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice.

Soo-Kyoung ChoiYoungin KwonSeonhee ByeonChae Eun HaamYoung-Ho Lee

Published in: PloS one (2020)

The treatment of AdipoRon improves vascular function in the mesenteric arteries of db-/db- mice through endothelium-independent mechanism. We suggest that MLCP activation through reduced phosphorylation of MYPT1 might be the dominant mechanism in the AdipoRon-induced vascular effect.

Keyphrases

metabolic syndrome
high glucose
insulin resistance
diabetic rats
adipose tissue
blood flow
oxidative stress
drug induced
high fat diet induced
protein kinase