Circulating Plasma Extracellular Microvesicle MicroRNA Cargo and Endothelial Dysfunction in Children with Obstructive Sleep Apnea.

Abdelnaby KhalyfaLeila Kheirandish-GozalAhamed A KhalyfaMona F PhilbyMaría Luz Alonso-ÁlvarezMeelad MohammadiRakesh BhattacharjeeJoaquin Terán-SantosLei HuangJorge AndradeDavid Gozal

Published in: American journal of respiratory and critical care medicine (2017)

These observations elucidate a novel role of exosomal miRNA-360 as a putative key mediator of vascular function and cardiovascular disease risk in children with underlying OSA and/or obesity, and identify therapeutic targets.

Keyphrases

obstructive sleep apnea
cardiovascular disease
young adults
type diabetes
metabolic syndrome
insulin resistance
weight loss
weight gain
adipose tissue
physical activity
sleep apnea
coronary artery disease
cardiovascular risk factors
high fat diet induced
cardiovascular events