Homoectoine Protects Against Colitis by Preventing a Claudin Switch in Epithelial Tight Junctions.

Karla F Castro-OchoaHilda Vargas-RoblesSandra Chánez-ParedesAlfonso Felipe-LópezRodolfo I Cabrera-SilvaMineko ShibayamaAbigail BetanzosPorfirio NavaErwin A GalinskiMichael Schnoor

Published in: Digestive diseases and sciences (2018)

While both ectoine and homoectoine have protective effects on the epithelial barrier during inflammation, only homoectoine completely prevented the inflammatory claudin switch in tight junctions. Thus, homoectoine may serve as diet supplement in IBD patients to reach or extend remission.

Keyphrases

end stage renal disease
oxidative stress
blood brain barrier
single molecule
ejection fraction
newly diagnosed
chronic kidney disease
ulcerative colitis
physical activity
peritoneal dialysis
rheumatoid arthritis
disease activity
patient reported outcomes
systemic lupus erythematosus