Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence.
Li PangOscar W H YeungKevin Tak Pan NgHui LiuJiye ZhuJiang LiuXinxiang YangTao DingWenqi QiuYuewen WangT L Shirley ChiuZhiwei ChenChung Mau LoKwan ManPublished in: Cancer research (2022)
IFNα secreted by plasmacytoid dendritic cells drives postoperative immunosuppression and early recurrence of hepatocellular carcinoma, providing new biomarkers and therapeutic targets to improve patient outcomes after surgical resection.