Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice.

Gitte R HinrichsKathrin WeyerUlla G FriisPer SvenningsenIda K LundRikke NielsenGéraldine MolletCorinne AntignacClaus BistrupBoye L JensenHenrik Birn

Published in: Acta physiologica (Oxford, England) (2019)

Nephrotic range glomerular proteinuria leads to urokinase-dependent intratubular plasminogen activation and γENaC cleavage which contribute to sodium accumulation.

Keyphrases

diabetic nephropathy
high glucose
dna binding
type diabetes
metabolic syndrome
transcription factor