Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer.
Amilcar Flores-MoralesTobias Borgtoft BergmannCharlotte LavalleeTanveer S BatthDong LinMads LerdrupStine FriisAnette BartelsGitte KristensenAgnieszka KrzyzanowskaHui XueLadan FazliKlaus H HansenMartin Andreas RøderKlaus BrassoJosé M MoreiraAnders BjartellYuzhuo WangJesper V OlsenColin C CollinsDiego Iglesias-GatoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
This study presents the first deep characterization of the proteome of NEPC and suggests that concomitant inhibition of REST and the p53 pathway would promote NEPC. We also identify SCGN as a novel prognostic marker in prostate cancer.
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