Non-neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats.

Francesco De LoguGaetano De SienaLorenzo LandiniMatilde MariniDaniel Souza Monteiro de AraujoValentina AlbaneseDelia PretiAntonia RomitelliMartina ChiecaMustafa TitizLuigi F IannonePierangelo Geppetti Romina Nassini

Published in: British journal of pharmacology (2022)

As found in mice, TRPA1 mediates mechanical allodynia associated with neurogenic inflammation and moderate nerve injury in rats. The channel contribution to mechanical hypersensitivity is a common feature in rodents and might be explored in humans.

Keyphrases

spinal cord injury
neuropathic pain
oxidative stress
machine learning
peripheral nerve
high intensity
spinal cord
deep learning
type diabetes
metabolic syndrome
high fat diet induced
adipose tissue
brain injury