Podocyte Injury in Diabetic Kidney Disease in a Mouse Model Involves TRPC6-mediated Calpain Activation Impairing Autophagy.
Yann SalemkourDilemin YildizLéa DionetDaan C 't HartKim A T VerheijdenRyuta SatoNassim MahtalJean-Daniel DelbetEmmanuel LetavernierMarion RabantAlexandre KarrasJohan van der VlagTom NijenhuisPierre-Louis TharauxOlivia LenoirPublished in: Journal of the American Society of Nephrology : JASN (2023)
Overall, we discovered a new mechanism that connects TRPC6 and calpain activity to impaired podocyte autophagy, increased podocyte injury, and development of proteinuria in the context of diabetic kidney disease. Therefore, targeting TRPC6 and/or calpain to restore podocyte autophagy might be a promising therapeutic strategy for diabetic kidney disease.