Incisionless MR-guided focused ultrasound: technical considerations and current therapeutic approaches in psychiatric disorders.
Thomas M M KinfeAndreas StadlbauerKlemens WinderRene HurlemannMichael BuchfelderPublished in: Expert review of neurotherapeutics (2020)
MRgFUS ablation is under clinical investigation (unblinded study design) for obsessive-compulsive disorders (OCDs) [capsulotomy; ALIC] and depression/anxiety disorders [capsulotomy] and has demonstrated an improvement in OCD and depression, although of preliminary character. Low-intensity ultrasound applications have been explored in Alzheimer´s disease (phase 1 study) and healthy subjects. Currently, limited evidence hinders comparison and selection between MRgFUS and noninvasive/invasive brain modulation therapies. However, comparative, sham-controlled trials are needed to reexamine the preliminary findings for the treatment of psychiatric disorders.
Keyphrases
- obsessive compulsive disorder
- depressive symptoms
- sleep quality
- magnetic resonance imaging
- double blind
- deep brain stimulation
- white matter
- open label
- cognitive decline
- resting state
- magnetic resonance
- clinical trial
- multiple sclerosis
- functional connectivity
- physical activity
- radiofrequency ablation
- atrial fibrillation
- combination therapy
- brain injury
- placebo controlled
- cerebral ischemia
- contrast enhanced ultrasound
- smoking cessation