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Incisionless MR-guided focused ultrasound: technical considerations and current therapeutic approaches in psychiatric disorders.

Thomas M M KinfeAndreas StadlbauerKlemens WinderRene HurlemannMichael Buchfelder
Published in: Expert review of neurotherapeutics (2020)
MRgFUS ablation is under clinical investigation (unblinded study design) for obsessive-compulsive disorders (OCDs) [capsulotomy; ALIC] and depression/anxiety disorders [capsulotomy] and has demonstrated an improvement in OCD and depression, although of preliminary character. Low-intensity ultrasound applications have been explored in Alzheimer´s disease (phase 1 study) and healthy subjects. Currently, limited evidence hinders comparison and selection between MRgFUS and noninvasive/invasive brain modulation therapies. However, comparative, sham-controlled trials are needed to reexamine the preliminary findings for the treatment of psychiatric disorders.
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