Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells.
Denisa-Mădălina ZălarCristina PopElena BuzduganBéla KissMaria-Georgia ŞtefanSteliana GhibuValentin-Adrian BâlteanuDoiniţa CrişanAlexandra Buruiană-SimicAdriana GrozavCristina Ionela MogoșanPublished in: Journal of clinical medicine (2021)
HLD was associated with hyperlipidemia, inflammation and oxidative stress. The overexpression of beta-3 receptors on endothelial cells increased aortic thickening in response to the HLD. Methotrexate and infliximab reduced oxidative stress and inflammation in all groups, but led to favorable histopathologic vascular results only in the transgenic groups.
Keyphrases
- oxidative stress
- endothelial cells
- diabetic rats
- high dose
- dna damage
- cell proliferation
- ischemia reperfusion injury
- induced apoptosis
- high glucose
- ulcerative colitis
- transcription factor
- aortic valve
- left ventricular
- high fat diet
- vascular endothelial growth factor
- type diabetes
- pulmonary artery
- heat shock
- signaling pathway
- low dose
- adipose tissue
- skeletal muscle
- metabolic syndrome
- pulmonary hypertension
- heart failure