Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults.

Michelle E FarrellKathryn V PappRachel F BuckleyHeidi I L JacobsAaron P SchultzMichael J ProperziPatrizia VanniniBernard J HanseeuwDorene M RentzKeith A JohnsonReisa A Sperling

Published in: Neurology (2022)

This study provides Class I evidence that in clinically normal older adults, emerging PET-detected AD pathology is associated with declining processing speeds and memory retrieval.

Keyphrases

physical activity
computed tomography
working memory
pet ct
cerebrospinal fluid
pet imaging