Parkinsonism Versus Concomitant Parkinson's Disease in Fragile X-Associated Tremor/Ataxia Syndrome.

Maria Jimena Salcedo-ArellanoMarisol Wendy Wolf-OchoaTiffany HongSarwat AminaFlora TassoneMirna LechpammerRandi HagermanVerónica Martínez-Cerdeño

Published in: Movement disorders clinical practice (2020)

This report expands our understanding of clinical symptoms and unusual presentations in patients with FXTAS and the concept that the parkinsonism found in FXTAS is sometimes indistinguishable from PD. We propose that FMR1 should be recognized as one of the exceptional genetic causes of parkinsonism with presynaptic dopaminergic loss and LBs.

Keyphrases

parkinson disease
drug induced
deep brain stimulation
genome wide
early onset
gene expression
copy number
sleep quality
physical activity
dna methylation