Dose-dependent bioavailability, absorption-rate limited elimination, and tissue distribution of the ATR inhibitor BAY-1895344 (elimusertib) in mice.

Brian F KieselJoshua J DeppasJianxia GuoRobert A PariseDavid A ClumpChristopher J BakkenistJan H Beumer

Published in: Cancer chemotherapy and pharmacology (2022)

Complex PK behavior was limited to absorption processes which may not be recapitulated clinically. Tissue partition coefficients may be used to contrast ATR inhibitors with respect to their efficacy and toxicity.

Keyphrases

dna damage response
magnetic resonance
oxidative stress
high fat diet induced
computed tomography
metabolic syndrome
adipose tissue
contrast enhanced
insulin resistance