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HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer.

Dorhyun JohngGonzalo TorgaCharles M EwingKideok JinJohn D NorrisDonald P McDonnellWilliam B Isaacs
Published in: The Prostate (2018)
Our study provides evidence for functional HOXB13-MEIS1 interactions in PCa. MEIS1 may contribute to the cancer-promoting actions of HOXB13 in cellular proliferation and gene regulation by prolonging HOXB13 half-life. Our data demonstrates that G84E is not a loss-of-function mutation that interferes with HOXB13 stability or ability to interact with MEIS1.
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