Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure.

Hozeifa Mohamed HassanXi LiangJiaojiao XinYingyan LuQun CaiDongyan ShiKeke RenJun LiQi ChenJiang LiPeng LiBeibei GuoHui YangJinjin LuoHeng YaoXingping ZhouWen HuJing JiangJun Li

Published in: BMC medicine (2024)

THBS1 might be an ACLF disease development-related biomarker, promoting inflammatory responses and hepatocellular apoptosis, that could provide clinicians with a new molecular target for improving diagnostic and therapeutic strategies.

Keyphrases

liver failure
hepatitis b virus
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
palliative care
cell death
drug induced
single molecule
intensive care unit