Dihydromyricetin Imbues Antiadipogenic Effects on 3T3-L1 Cells via Direct Interactions with 78-kDa Glucose-Regulated Protein.

Binmei SunDeguan TanDongjin PanMargaret R BakerZhibin LiangZhizheng WangJianjun LeiShaoqun LiuChing Yuan HuQingxiao Li

Published in: The Journal of nutrition (2022)

DHM targets GRP78 in vitro. DHM is able to reduce lipid droplet formation in 3T3-L1 cells through a mode of action that is plausibly associated with direct interactions between GRP78 and DHM, which is a step forward in determining potential applications of DHM as an anti-obesity agent.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell cycle arrest
type diabetes
metabolic syndrome
insulin resistance
oxidative stress
transcription factor
cell death
risk assessment
binding protein
high fat diet induced
pi k akt