A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2-Induced Glycolytic Reprogramming in Glioblastoma.
Corinne BeinatChirag B PatelTom HaywoodSurya MurtyLewis NayaJessa B CastilloSamantha T ReyesMegan PhillipsPablo BuccinoBin ShenJun Hyung ParkMary Ellen I KoranIsrat S AlamMichelle L JamesDawn HolleyKim HalbertHarsh GandhiJoy Q HeMonica GranucciEli JohnsonDaniel Dan LiuNobuko UchidaRahul SinhaPauline ChuDonald E BornGeoffrey I WarnockIrving WeissmanMelanie Hayden-GephartMehdi KhalighiTarik F MassoudAndrei H IagaruGuido A DavidzonReena ThomasSeema NagpalLawrence D RechtSanjiv Sam GambhirPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
We developed and translated [18F]DASA-23 as a new tracer that demonstrated the visualization of aberrantly expressed PKM2 for the first time in human subjects. These results warrant further clinical evaluation of [18F]DASA-23 to assess its utility for imaging therapy-induced normalization of aberrant cancer metabolism.