Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade.

Imran G HousePeter SavasJunyun LaiAmanda X Y ChenAmanda J OliverZhi L TeoKirsten L ToddMelissa A HendersonLauren GiuffridaEmma V PetleyKevin SekSherly MardianaTuba N GideCamelia QuekRichard A ScolyerGeorgina V Long James S Wilmott Sherene LoiPhillip K DarcyPaul A Beavis

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

These data underline the fundamental importance of macrophage-derived CXCR3 ligands for the therapeutic efficacy of ICB and highlight the potential of manipulating this axis to enhance patient responses.

Keyphrases

immune response
adipose tissue
case report
electronic health record
toll like receptor
dendritic cells
machine learning
cell migration
inflammatory response