Induction and exacerbation of subacute cutaneous lupus erythematosus following mRNA-based or adenoviral vector-based SARS-CoV-2 vaccination.

Alexander KreuterM J Licciardi-FernandezS-N BurmannB BurkertF OelligA-L Michalowitz

Published in: Clinical and experimental dermatology (2021)

Evidence is accumulating that COVID-19 vaccines might induce or exacerbate autoimmune rheumatic diseases. The currently available COVID-19 vaccines include mRNA and recombinant adenoviral vector vaccines, both encoding SARS-CoV-2 spike protein production as the primary target for neutralizing antibodies. We report a case of subacute cutaneous lupus erythematosus (SCLE) following mRNA vaccination with the Pfizer mRNA vaccine BNT162b2, and summarize the current literature on CLE occurring after COVID-19 vaccination.

Keyphrases

sars cov
respiratory syndrome coronavirus
binding protein
coronavirus disease
systemic lupus erythematosus
disease activity
systematic review
chronic obstructive pulmonary disease
multiple sclerosis
amino acid
intensive care unit
zika virus
mechanical ventilation
drug induced
protein protein