Effects of PreOperative radiotherapy in a preclinical glioblastoma model: a paradigm-shift approach.

Beatriz I Fernandez-Gil Paula Schiapparelli Juan P Navarro-Garcia de LlanoAndrea Otamendi-LopezMaria Jose Ulloa-NavasLoizos MichaelidesCarla A Vazquez-RamosSteven M HerchkoMelissa E MurrayYesesri CherukuriYan W AsmannDaniel M Trifiletti Alfredo Quinones-Hinojosa

Published in: Journal of neuro-oncology (2024)

This is the first preclinical study showing feasibility and longer overall survival using neoadjuvant radiotherapy before GBM resection in a mammalian model. This suggests strong superiority for new clinical radiation strategies. Further studies and trials are required to confirm our results.

Keyphrases

locally advanced
early stage
radiation induced
rectal cancer
radiation therapy
cell therapy
lymph node
squamous cell carcinoma
bone marrow
case control