Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling.

Diego A PedrozaVenkatesh RajamanickamRamadevi SubramaniAlejandra BencomoAdriana GalvezRajkumar Lakshmanaswamy

Published in: British journal of cancer (2020)

Our data demonstrate that PGRMC1 plays a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.

Keyphrases

pi k akt
cell cycle arrest
small cell lung cancer
signaling pathway
induced apoptosis
epidermal growth factor receptor
tyrosine kinase
cell death
cell proliferation
endoplasmic reticulum stress
artificial intelligence