Electroacupuncture promotes the survival and synaptic plasticity of hippocampal neurons and improvement of sleep deprivation-induced spatial memory impairment.

Wenya PeiFanqi MengQingwen DengBaobao ZhangYuan GuBoyu JiaoHaoyu XuJiuqing TanXin ZhouZhiling LiGuanheng HeJingwen RuanYing Ding

Published in: CNS neuroscience & therapeutics (2021)

Electroacupuncture alleviates SD-induced spatial memory impairment by promoting hippocampal neurogenesis and synaptic plasticity via activation of BDNF/TrkB/Erk signaling, which provided evidence for EA as a therapeutic strategy for countering the adverse effects of SD on cognition.

Keyphrases

cerebral ischemia
high glucose
diabetic rats
working memory
spinal cord
signaling pathway
cell proliferation
physical activity
emergency department
mild cognitive impairment
pi k akt
spinal cord injury
depressive symptoms
blood brain barrier
sleep quality
stress induced