Login / Signup

Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models.

Malinee ThaneeSureerat PadthaisongManida SuksawatHasaya DokduangJutarop PhetcharaburaninPoramate KlanritAttapol TitapunNisana NamwatArporn WangwiwatsinPrakasit Sa-NgiamwiboolNarong KhuntikeoHideyuki SayaWatcharin Loilome
Published in: Cancer & metabolism (2021)
SSZ could improve CCA therapy by sensitization to CIS through killing CD44v9-positive cells and modifying the metabolic pathways, in particular tryptophan degradation (i.e., kynurenine pathway, serotonin pathway) and nucleic acid metabolism.
Keyphrases
  • induced apoptosis
  • nucleic acid
  • cell cycle arrest
  • cell death
  • oxidative stress
  • mesenchymal stem cells
  • cell proliferation
  • bone marrow
  • cell therapy