Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models.

Malinee ThaneeSureerat PadthaisongManida SuksawatHasaya DokduangJutarop PhetcharaburaninPoramate KlanritAttapol TitapunNisana NamwatArporn WangwiwatsinPrakasit Sa-NgiamwiboolNarong KhuntikeoHideyuki SayaWatcharin Loilome

Published in: Cancer & metabolism (2021)

SSZ could improve CCA therapy by sensitization to CIS through killing CD44v9-positive cells and modifying the metabolic pathways, in particular tryptophan degradation (i.e., kynurenine pathway, serotonin pathway) and nucleic acid metabolism.

Keyphrases

induced apoptosis
nucleic acid
cell cycle arrest
cell death
oxidative stress
mesenchymal stem cells
cell proliferation
bone marrow
cell therapy