A novel patient-derived organoids-based xenografts model for preclinical drug response testing in patients with colorectal liver metastases.

Mi JianLi RenGuodong HeQi LinWentao TangYijiao ChenJingwen ChenTianyu LiuMeiling JiYe WeiWenju ChangJianmin Xu

Published in: Journal of translational medicine (2020)

This PDOX-LM model provides a more convenient and informative platform for preclinical testing of individual tumors by retaining the histologic and genetic features of donor liver metastases. This technology holds great promise to predict treatment sensitivity for patients with CLMs undergoing chemotherapy.

Keyphrases

liver metastases
cell therapy
stem cells
emergency department
high throughput
gene expression
locally advanced
copy number
machine learning
mesenchymal stem cells
deep learning
single cell