Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37.

Jinxiao ChenDa WoEn MaHongwei YanJun PengWeidong ZhuYong FangDan-Ni Ren

Published in: Cell communication and signaling : CCS (2019)

LRP5 deletion attenuates cell proliferation via destabilization of NUP37, in a β-catenin-independent manner. LRP5 therefore acts as a genuine regulator of YAP/TEAD signaling via maintaining the integrity of the NPC, and implicates a therapeutic strategy in targeting LRP5 for inhibiting liver cancer cell proliferation.

Keyphrases

cell proliferation
low density lipoprotein
cell cycle
pi k akt
signaling pathway
transcription factor