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Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction.

Tianpeng WangJingchen ShaoShamit KumarMohammad Wessam AlnouriJorge CarvalhoStefan GüntherCornelius KraselKate T MurphyMoritz BünemannStefan OffermannsNina Wettschureck
Published in: Circulation research (2024)
Our data show that GPRC5C regulates Ang II-dependent vascular contraction by facilitating AT1 receptor-ligand binding and signaling.
Keyphrases
  • smooth muscle
  • angiotensin ii
  • angiotensin converting enzyme
  • vascular smooth muscle cells
  • high glucose
  • diabetic rats
  • electronic health record
  • big data
  • drug induced
  • oxidative stress
  • data analysis
  • drug discovery