Proinflammatory CX3CR1+CD59+Tumor Necrosis Factor-Like Molecule 1A+Interleukin-23+ Monocytes Are Expanded in Patients With Ankylosing Spondylitis and Modulate Innate Lymphoid Cell 3 Immune Functions.
Francesco CicciaGiuliana GugginoMichael ZengRanjeny ThomasVidya RanganathanArifur RahmanRiccardo AlessandroAroldo RizzoLaura SaievaFederica MacalusoSergio PeraltaDiana Di LibertoFrancesco DieliPaola CiprianiRoberto GiacomelliDominique BaetenNigil HaroonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
Proinflammatory CX3 CR1+CD59+TL1A+IL-23+ MNPs are expanded in AS patients and display a specific proinflammatory transcriptome profile. Given the ability of these cells to support ILC3 expansion, they may promote a sustained proinflammatory status in AS.
Keyphrases
- ankylosing spondylitis
- end stage renal disease
- rheumatoid arthritis
- single cell
- induced apoptosis
- ejection fraction
- nk cells
- newly diagnosed
- chronic kidney disease
- gene expression
- peritoneal dialysis
- cell therapy
- dendritic cells
- mesenchymal stem cells
- immune response
- peripheral blood
- endoplasmic reticulum stress
- dna methylation
- signaling pathway
- cell death