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Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage.

Maria C HeinzNiek A PetersKoen C OostRik G H LindeboomLisa van VoorthuijsenArianna FumagalliMirjam C van der NetGustavo de MedeirosJoris H HagemanIngrid Verlaan-KlinkInne H M Borel RinkesPrisca LiberaliMartijn GloerichJacco van RheenenMichiel VermeulenOnno W KranenburgHugo J G Snippert
Published in: Cancer research (2022)
Characterization of the cell type dynamics, composition, and transcriptome of early colorectal cancer liver metastases reveals that failure to establish cellular heterogeneity through YAP-controlled epithelial self-organization prohibits the outgrowth of micrometastases. See related commentary by LeBleu, p. 1870.
Keyphrases
  • liver metastases
  • single cell
  • gene expression
  • rna seq
  • genome wide
  • dna methylation
  • drug induced