Bioinspired Hybrid Nanostructured PEEK Implant with Enhanced Antibacterial and Anti-inflammatory Synergy.
Ji AoXin ZhangYunhao YouYuxiang ChenZequan LiuJie GaoChenyang QinLingwan HaoJie ZhaoRujian JiangPublished in: ACS applied materials & interfaces (2024)
Implant-associated infections and excessive immune responses are two major postsurgical issues for successful implantation. However, conventional strategies including antibiotic treatment and inflammatory regulation are always compromised due to the comodification of various biochemical agents and instances of functional interference. It is imperative to provide implant surfaces with satisfactory antibacterial and anti-inflammatory properties. Here, a dual-effect nanostructured polyetheretherketone (PEEK) surface (NP@PDA/Zn) with bionic mechano-bactericidal nanopillars and immobilized immunomodulatory Zn 2+ is designed. The constructed hybrid nanopillars display remarkable antibacterial performance against Gram-negative and Gram-positive strains through the synergy of physical and chemical bactericidal effects imposed by nanopillars and Zn 2+ . Meanwhile, the immunoregulatory property is evaluated through the investigation of macrophage polarization both in vitro and in vivo, and the results reveal that NP@PDA/Zn could downregulate the expression of M1-related cytokines and decrease the M1 macrophage recruitment to lower the inflammatory response. Notably, the surface exhibited exceptional biocompatibility with discerning biocidal activity between bacterial and mammalian cells and antioxidant performance that effectively scavenges ROS, minimizing potential cytotoxicity. Taken together, NP@PDA/Zn presents a convenient and promising strategy of combining synergistic bactericidal activity and inflammatory regulation without any mutual interference, which can support the development of multifunctional implant-associated materials.
Keyphrases
- anti inflammatory
- gram negative
- heavy metals
- multidrug resistant
- soft tissue
- inflammatory response
- immune response
- oxidative stress
- silver nanoparticles
- escherichia coli
- mental health
- risk assessment
- physical activity
- dna damage
- wastewater treatment
- cancer therapy
- cell death
- gene expression
- dna methylation
- biofilm formation
- long non coding rna
- mass spectrometry
- climate change
- candida albicans
- single cell
- smoking cessation
- dendritic cells