METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression.
Xiang ChenWang GongXiaoyan ShaoTianshu ShiLei ZhangJian DongYong ShiSiyu ShenJianghui QinQing JiangBaosheng GuoPublished in: Annals of the rheumatic diseases (2021)
Our study revealed the important role of FLS senescence in OA progression. Targeted METTL3 inhibition could alleviate the senescence of FLS and limit OA development in experimental animal models, providing a potential strategy for OA therapy.