Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis.
Mirjam PodgoricaElsa DrivetJonas Krag VikenAlyssa RichmanJohanne VestbøstadPeter SzodorayAnn Kristin KvamHilde Skuterud WikGeir Erland TjønnfjordLudvig A MuntheSeth E FrietzeHilde SchjervenPublished in: European journal of haematology (2024)
We demonstrate that RNA-seq is an effective tool for precision medicine in B-ALL by providing comprehensive molecular profiling of leukemia cells, identifying subtype and oncogenic lesions, and stratifying patients for appropriate therapy.
Keyphrases
- rna seq
- single cell
- acute lymphoblastic leukemia
- end stage renal disease
- copy number
- genome wide
- newly diagnosed
- ejection fraction
- induced apoptosis
- chronic kidney disease
- prognostic factors
- bone marrow
- transcription factor
- cell cycle arrest
- patient reported outcomes
- allogeneic hematopoietic stem cell transplantation
- peritoneal dialysis
- dna methylation
- signaling pathway
- cell death
- cell proliferation
- young adults
- mesenchymal stem cells
- cell therapy
- pi k akt
- childhood cancer