Liver X Receptor Alpha Activation Inhibits Autophagy and Lipophagy in Hepatocytes by Dysregulating Autophagy-Related 4B Cysteine Peptidase and Rab-8B, Reducing Mitochondrial Fuel Oxidation.
Yun Seok KimHyeon Joo NamChang Yeob HanMin Sung JooKiseok JangDae Won JunSang Geon KimPublished in: Hepatology (Baltimore, Md.) (2021)
LXRα inhibits autophagy in hepatocytes through down-regulating ATG4B and Rab-8B by transcriptionally activating microRNA let-7a-2 and microRNA 34a genes and suppresses mitochondrial biogenesis and fuel consumption. This highlights a function of LXRα that culminates in the progression of liver steatosis and steatohepatitis, and the identified targets may be applied for a therapeutic strategy in the treatment of NAFLD.
Keyphrases
- signaling pathway
- oxidative stress
- cell death
- endoplasmic reticulum stress
- liver injury
- insulin resistance
- genome wide
- high fat diet
- drug induced
- type diabetes
- dna methylation
- hydrogen peroxide
- gene expression
- transcription factor
- adipose tissue
- skeletal muscle
- genome wide identification
- fluorescent probe
- bioinformatics analysis