m 1 A RNA Modification in Gene Expression Regulation.

N 1 -methyladenosine (m 1 A) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Recent studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of m 1 A RNA modification in gene regulation and biological processes. In this review, we focus on progress in the study of m 1 A methyltransferases, m 1 A demethylases and m 1 A-dependent RNA-binding proteins and highlight the biological mechanisms and functions of m 1 A RNA modification, as well as its association with human disease. We also summarize the current understanding of detection approaches for m 1 A RNA modification.