Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice.

Prashant KadamElissavet NtemouYoni BaertSven Van LaereDorien Van SaenEllen Goossens

Published in: Stem cell research & therapy (2018)

Co-transplanting SSCs and TGFß1-treated MSCs significantly improves the recovery of endogenous SSCs and increases the homing efficiency of transplanted SSCs. This procedure could become an efficient method to treat infertility in a clinical setup, once the safety of the technique has been proven.

Keyphrases

stem cell transplantation
mesenchymal stem cells
high dose
umbilical cord
cell therapy
bone marrow
transforming growth factor
minimally invasive
high fat diet induced
low dose
adipose tissue
epithelial mesenchymal transition
signaling pathway