DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.

Viviana TorresJesica Pérez-MontesinoRubén Fernández-SantiagoManel FernándezAna CamaraYaroslau ComptaMaría-José MartíÀlex Guerra BeltranJosé RiosFrancesc ValldeoriolaMario Ezquerra

Published in: Annals of clinical and translational neurology (2024)

Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.

Keyphrases

genome wide
uric acid
risk factors
copy number
human health
dna methylation
metabolic syndrome
high resolution