Prognostic value of baseline metabolic tumor volume in children and adolescents with intermediate-risk Hodgkin lymphoma treated with chemo-radiation therapy: FDG-PET parameter analysis in a subgroup from COG AHOD0031.

Sarah Allison MilgromJihyun KimAlin ChirindelJongho KimQinglin PeiLu ChenAllen BuxtonSandy KesselJeffrey LealKathleen M McCartenBradford S Hoppe Suzanne L WoldenCindy L SchwartzDebra L FriedmanKara M KellySteve Y Cho

Published in: Pediatric blood & cancer (2021)

Multiple baseline PET-derived volumetric parameters were associated with EFS. MTV2BP was highly associated with EFS when controlling for disease bulk and response to chemotherapy. Incorporation of baseline MTV into risk-based treatment algorithms may improve outcomes in intermediate-risk HL.

Keyphrases

radiation therapy
hodgkin lymphoma
pet ct
positron emission tomography
computed tomography
machine learning
locally advanced
deep learning
photodynamic therapy
cancer therapy
drug delivery
radiation induced
insulin resistance
open label
study protocol