MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4.

Elisa MartinoNunzia D'OnofrioAnna BalestrieriLuigi MeleCelestino SarduRaffaele MarfellaGiuseppe CampanileMaria Luisa Balestrieri

Published in: Cellular & molecular biology letters (2023)

Our in vitro findings suggested the miR-15b-5p-SIRT4 axis as a suitable target for LPS-induced inflammatory pathways occurring in sepsis, and provide additional knowledge on the beneficial effect of i-PCSK9 in preventing vascular damage by targeting SIRT4.

Keyphrases

lipopolysaccharide induced
inflammatory response
lps induced
oxidative stress
ischemia reperfusion injury
healthcare
acute kidney injury
low density lipoprotein