Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones.

Gabriella MartelloEzgi OzturkGeorgia HarrisCornelius PaulTerence J O'BrienNigel Charles Jones

Published in: Epilepsia (2023)

These results suggest that GAERS exhibit elevations in stress hormones, and this may contribute to seizures. Inhibiting corticosterone synthesis with metyrapone prevents seizures in GAERS, and shows potential for repurposing this drug as a future antiseizure medication.

Keyphrases

temporal lobe epilepsy
adverse drug
healthcare
stress induced
signaling pathway
current status
emergency department
mouse model
gene expression
copy number
dna methylation
electronic health record