Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies.
Shraddha S RaneRebecca J DearmanIan KimberShahid UddinStephen BishopMaryam ShahAdrian PodmoreAlain PluenJeremy P DerrickPublished in: Pharmaceutical research (2019)
The results indicate a Th1-skewing of the immune response by aggregates and show that murine rmHSP70 selectively modulates the immune response to mAb aggregates, but not monomer. These data suggest that heat shock protein impurities can selectively accumulate by binding to mAb aggregates and thus influence immunogenic responses to therapeutic proteins.