Enhancing Viability of Human Embryonic Stem Cells during Cryopreservation via RGD-REP-Mediated Activation of FAK/AKT/FoxO3a Signaling Pathway.
Jeong Hee KimJeong In ChoiYoung Hyun CheSu Haeng SungHojae LeeSun LeeJae-Hoon ParkYun-Il LeeYoung-Sam LeeWon Bae JeonYong Jun KimPublished in: Tissue engineering and regenerative medicine (2023)
RGD-REP, as a ligand for integrin protein, improves the survival and maintenance of hPSCs during cryopreservation by activating survival signals via the RGD motif. These results have potential implications for improving the efficiency of stem cell usage in both research and therapeutic applications.
Keyphrases
- signaling pathway
- embryonic stem cells
- pi k akt
- stem cells
- epithelial mesenchymal transition
- endothelial cells
- induced apoptosis
- free survival
- cell migration
- cell proliferation
- induced pluripotent stem cells
- transcription factor
- mesenchymal stem cells
- amino acid
- small molecule
- climate change
- endoplasmic reticulum stress