Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.

Yuchen GuoJun WangBente BenedictChen YangFrank van GemertXuhui MaDongmei GaoHui WangShu ZhangCor LieftinkRoderick L BeijersbergenHein Te RieleXiaohang QiaoQiang GaoChong SunWenxin QinRené BernardsCun Wang

Published in: Genome medicine (2021)

Our data highlights the potential of targeting ATR-CHK1 signaling, either alone or in combination with CDC7 inhibition, for the treatment of liver cancer.

Keyphrases

dna damage response
cancer therapy
cell cycle
electronic health record
big data
drug delivery
risk assessment
oxidative stress
stress induced
human health
dna damage
climate change
smoking cessation
replacement therapy