Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.
Yuchen GuoJun WangBente BenedictChen YangFrank van GemertXuhui MaDongmei GaoHui WangShu ZhangCor LieftinkRoderick L BeijersbergenHein Te RieleXiaohang QiaoQiang GaoChong SunWenxin QinRené BernardsCun WangPublished in: Genome medicine (2021)
Our data highlights the potential of targeting ATR-CHK1 signaling, either alone or in combination with CDC7 inhibition, for the treatment of liver cancer.