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Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.

Yuchen GuoJun WangBente BenedictChen YangFrank van GemertXuhui MaDongmei GaoHui WangShu ZhangCor LieftinkRoderick L BeijersbergenHein Te RieleXiaohang QiaoQiang GaoChong SunWenxin QinRené BernardsCun Wang
Published in: Genome medicine (2021)
Our data highlights the potential of targeting ATR-CHK1 signaling, either alone or in combination with CDC7 inhibition, for the treatment of liver cancer.
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