Th17/1 and ex-Th17 cells are detected in patients with polyarticular juvenile arthritis and increase following treatment.
Stephanie WoodJustin BranchPriscilla VasquezMarietta M DeGuzmanAmanda BrownAnna Carmela Sagcal-GironellaSaimun SinglaAndrea RamirezTiphanie P VogelPublished in: Pediatric rheumatology online journal (2024)
Patients with polyJIA have increased baseline Th17 cells, potentially reflecting higher tonic STAT3 activation in vivo. These quantifiable immune markers may identify patients that would benefit upfront from pathway-focused biologic therapies. Our data also suggest that inflammatory CD4 + T cell subsets not detected in controls but increased in post-treatment samples should be further evaluated as a tool to stratify patients in remission on medication. Future work will explore these proposed diagnostic and prognostic biomarkers.
Keyphrases
- end stage renal disease
- ejection fraction
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- rheumatoid arthritis
- prognostic factors
- healthcare
- emergency department
- peritoneal dialysis
- cell cycle arrest
- oxidative stress
- cell proliferation
- juvenile idiopathic arthritis
- systemic lupus erythematosus
- patient reported outcomes
- cell death
- machine learning
- electronic health record
- smoking cessation
- ulcerative colitis
- data analysis