Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder.

Thiago Wendt ViolaJaqueline Bohrer SchuchDiego Luiz RovarisRafael GenoveseLucca TondoBreno Sanvicente-VieiraAline ZaparteRenata Basso CupertinoBruna Santos da SilvaClaiton Henrique Dotto BauRodrigo Grassi-Oliveira

Published in: Journal of neural transmission (Vienna, Austria : 1996) (2019)

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

Keyphrases

autism spectrum disorder
gene expression
dna methylation
copy number
transcription factor
prefrontal cortex